StatPearls MCP Server connects AI assistants to peer-reviewed medical knowledge from the StatPearls clinical database on NCBI. It enables searching for diseases and medical conditions and retrieves comprehensive, reliable content formatted in Markdown for seamless AI consumption. Key features of StatPearls MCP Server: - Search for diseases, conditions, and medical topics from StatPearls - Retrieve peer-reviewed clinical summaries and medical information - Auto-convert HTML content to well-formatted Markdown for AI-friendly processing - Integrate trusted medical knowledge directly into AI conversations via the Model Context Protocol - Access self-service executables for Windows, Mac, and Linux with no additional dependencies - Installable via Smithery for automatic setup with Claude Desktop

StatPearls MCP Server

[](https://smithery.ai/server/@jpoles1/statpearls-mcp)

A Model Context Protocol (MCP) server that fetches disease information from StatPearls, a trusted source of peer-reviewed medical content.

Give your AI system a relaible source of medical knowledge for its next conversation.

Features

If you don't already have a Model Context Protocol (MCP) client:

If you are a casual user, you can use Claude Desktop to get started using MCP servers. It is a free and open-source desktop application that allows you to run MCP servers locally and connect to them.

If you are a power user/developer, I recommend using VSCode with the RooCode extension which enables you to connect in MCP servers to your development environment for infinite possibilities!

Installation

Once you have an MCP-capable AI client, you can run this server locally.

The easiest way to get up and running is to download the appropriate executable/binary for your OS from the releases page. This will give you a self-contained executable that you can run without any additional setup.

Place this executable in a directory of your choice. Then simply add the following to your mcp_settings.json file:

#### For Windows:

{
  "mcpServers": {
    ...
    "statpearls": {
      "command": "{path_to_executable_here}\\statpearls-mcp.exe"
    },
    ...
  }
}
#### For Mac/Linux:

Installing via Smithery
To install statpearls-mcp for Claude Desktop automatically via Smithery:

For Developers:
You can also run the server from source. This requires Bun to be installed on your system.
  1. Clone the repository
  2. Install dependencies (bun install)
  3. Compile the server (bun run build)
  4. Now you can add the server to your mcp_settings.json file:
  

Tool Definition
The server provides a single tool:
statpearls_disease_info: Fetches comprehensive, reliable medical information about diseases from StatPearls.
Input Schema

query: Disease or medical condition to search for (required)
format_options: Optional formatting preferences
  - includeToc: Whether to include a table of contents (default: true)
  - maxLength: Maximum length of the returned content in characters (default: 50000)
Example Output
The tool returns formatted Markdown content with:
Title and source information
Table of contents (optional)
Structured sections including etiology, epidemiology, pathophysiology, clinical features, diagnosis, treatment, and prognosis (when available)
Development
Project Structure